| abstract |
FIELD: medicine, pharmaceutics. n SUBSTANCE: invention relates to dispersed pills, containing 4-tret-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-(pyrimidine-2-yl)pyrimidine-4-yl]benzolsulfonamide (bosentan). Dispersed pill of bosentan also includes one or more fillers, one or more disintegrating agents, one or more glidants, one or more acidifying agents, one or more flavours, one of more sweeteners, one or more oiling agents. Dispersed pill of bosentan is fully destroyed in water at the temperature of 15-22°C for not more than 5 minutes. Dispersed pill of bosentan is produced by method of direct pressing. n EFFECT: production of medicinal agent for treatment of pulmonary arterial hypertension. n 4 cl, 1 dwg, 3 tbl, 3 ex |