| abstract |
FIELD: chemistry. ^ SUBSTANCE: invention relates to novel indoline-sulphonamides of formula (I): , where R1 denotes H, halogen; R2 denotes I I, Ar, Ar-C(O)-, Ar-CH2-, Ar-SO2-, Ar-O-C(O)-, , R"-C(O)-, where Ar is unsubstituted phenyl or phenyl which is substituted with one substitute selected from a group comprising halogen, NO2, CN, alkoxy, CH3OC(O)-, or denotes a six-member heteroaryl with one N atom as a heteroatom, or is its N-oxide derivative, or denotes a five-member heteroaryl with one S or O atom as a heteroatom; R' and R" independently denote C1-C10 alkyl; R3 denotes C1-C10 alkyl. ^ EFFECT: compounds can inhibit tubulin polymerisation which enables their use in cancer treatment. ^ 16 cl, 25 ex |