| abstract |
FIELD: medicine, pharmaceutics. n SUBSTANCE: there are described compounds of the following structure or their salts: where A, B, R 2 , R 4 , R 6 , R 7 , R 10 , R 16 , R 17α , R 17β , Z, Y, X have the values specified in the description. Some of these compounds exhibiting tissue-specific antiandrogen activity and tissue-specific androgen activity can be applied for treating or reducing risk of the diseases associated with androgen stimulation loss. n EFFECT: preparation of the compounds which reducing probability of the androgen-dependent diseases, such as prostate cancer, benign prostate hyperplasia, polycystic ovary syndrome, acne, hirsutism, seborrhoea, etc. n 41 cl, 176 ex, 4 tbl |