| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_830546519f5f26ac1c4c6d577378e060 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-13
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B82B1-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-63
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-577 |
| filingDate |
2008-11-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2010-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3aec059139f34a5cf07517622a3e5ff6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_602dbc7f84c19100d8c92e31d0fc46a5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_edbd3a5db902c09866701c82ea14c1ca
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6768a6600d4f3ee2f9d21c7a52c7ad32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_95ca4911f2bbd5cb437eef057b821f02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5965a360a417e3aef8dc4a41ed0354f0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3272f7d1950800710b06a8f1532dd1d3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_db06a55c729f91b9f03816fa39424c37
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8ec362b3586b96a8558565edc75ea4c7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b98553ae031e568be085278e8e3b5396
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5ce783815eebec84021287d565c8f906
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_65e12285fd943fd0610ae525369a2de9 |
| publicationDate |
2010-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
RU-2395522-C1 |
| titleOfInvention |
Vegf binding v93 nanoantibody and method of obtaining said antibody, v93-coding nucleotide sequence and vector containing said sequence, endothelial cell proliferation inhibition method |
| abstract |
FIELD: chemistry; biochemistry. n SUBSTANCE: invention relates to immunology and biotechnology. The invention discloses a monomer single-strand V93 nanoantibody which can bind and inhibit the human vascular endothelial growth factor. The invention describes a nucleotide sequence which codes the V93 nanoantibody and its expression vector with extra epitope(s) on the C-end for detection and extraction and a signal peptide on the N-end. The invention discloses a method of obtaining the V93 nanoantibody, a method of inhibiting proliferation of endothelial cells using the V93 nanoantibody, as well as use of the V93 nanoantibody for qualitative and quantitative determination of VEGF in a sample. n EFFECT: use of the invention provides high-affinity neutralising monovalent single-strand nanoantibodies which are more resistant to external factors (temperature, pH) and cheaper to produce compared to conventional VEGF antibodies, which can be useful in medicine for treating and diagnosing diseases associated with regulation of the activity of the vascular endothelial growth factor (VEGF). n 7 cl, 7 dwg, 6 ex |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2454427-C2 |
| priorityDate |
2008-11-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |