| abstract |
FIELD: chemistry. n SUBSTANCE: invention relates to novel compounds of general formula n , where R 1 is a n or or or group, R 2 is morpholine or OR' or N(R") 2 ; R' is a lower alkyl, a lower alkyl substituted with a halogen, or -(CH 2 ) n -cycloalkyl; R" is a lower alkyl; R is NO 2 or SO 2 R'; R 4 is hydrogen, hydroxy, halogen, NO 2 , lower alkoxy, SO 2 R' or C(O)OR"; R 5 /R 6 /R 7 denote hydrogen, halogen, lower alkyl; X'/X 1 denote CH or N, provided that X 1 /X 1' are not CH at the same time; X 2 is O or S; n equals 0 or 1, and to their pharmaceutically active acid-addition salts. The invention also relates to a drug. n EFFECT: obtaining novel biologically active compounds which are active as glycine transporter 1 inhibitors. n 11 cl, 24 ex, 1 tbl |