http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2395092-C2

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classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53
filingDate 2008-09-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2010-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2804de36ba2bbc0c56e6228eed12f1ac
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5c431eca2692250ea0aef0961f19a096
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publicationDate 2010-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber RU-2395092-C2
titleOfInvention Method of determining antibodies to tuberculosis germ
abstract FIELD: medicine. n SUBSTANCE: sample is in contact with membrane testing strip and initiates movement of reagents along membrane testing strip which are contained in sample or laid on the membrane. For detecting antibodies two antigenic reagents are used - immobilised in analytical zone of the testing strip Mycobacterium tuberculosis antigen and an antigen conjugated with colloidal gold particles. Due to presence of antibodies in at least two antigen-binding sites in contact of the test strip with the sample in analytical area formation of immune complexes takes place which consist of immobilised on membrane antigen molecules contained in the sample of antibodies to the antigen Mycobacterium tuberculosis and conjugated antigen Mycobacterium tuberculosis with particles of colloidal gold. Complexes are detected visually or using an optical detector. n EFFECT: method enables to provide a high surface density of binding sites of antibodies to antigens of Mycobacterium tuberculosis on colloidal gold particles and thus a more intense staining of analytical zone of the testing strip. n 2 ex, 1 dwg
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priorityDate 2008-09-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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