| abstract |
FIELD: medicine. n SUBSTANCE: invention relates to medicine and cosmetology and represents derivatives of hyaluronic acid structurally organised with unilamellar liposomes or in them, for injection as soft tissue filler and/or for correction of skin defects and/or for integration into synovial fluid or for replacement of synovial fluid in case of intra-articular treatment of osteochondrosis, where said derivatives are selected from group including esters, internal esters, amides, O-sulphated derivatives, percarboxylised derivatives and deacetilated derivatives, where molecular mass of hyaluronic acid is within the range from 50000 to 3×10 6 Da, liposomes are formed by phospholipids and concentration of phospholipid is within the range from 0.1 to 50 mg/ml. n EFFECT: invention relates preservation of said fillers during long time in the area of their application, which considerably reduced necessity of their frequent introduction with preservation of properties of biocompatibility, safety and easiness of processing. n 12 cl, 5 ex |