| abstract |
FIELD: chemistry. n SUBSTANCE: in the formula (I) , R 1 is metoxymethyl; R 2 is selected out of -C(O)NR 4 R 5 , -SO 2 NR 4 R 5 , -S(O) P R 4 and HET-2; R 3 is selected out of halogeno, fluoromethyl, metoxy and cyano; HET-1 is 5- or 6-member heteroaryl ring linked by C atom and containing nitrogen atom in 2 position and possibly 1 or 2 additional ring heteroatoms selected independently out of O, N and S, which is possible substituted at available carbon atom or at ring nitrogen atom by 1 substitute selected independently out of R 6 , provided that it would not cause ring quaternisation. The other radicals are indicated in the invention claim. Also invention refers to pharmaceutical composition containing claimed compound as active component, and methods of obtaining compound of the formula (I). n EFFECT: compounds with glucokinase inhibition effect. n 19 cl, 2 tbl, 61 ex |