abstract |
FIELD: chemistry. n SUBSTANCE: claimed compounds show effect on receptor activated by peroxysome proliferate δ (PPARδ). In formula I: [Formula I] , [Formula VII] , [Formula VI] , A is R 1 is C 1-4 alkyl group; R 3 groups are different and denote halogen atom or C 1-4 alkyl group substituted or unsubstituted by halogen; R 4 is R 5 is hydrogen atom or hydroxyl group; the other radicals are as defined in the invention claim. Also invention refers to methods of compound I obtainment, to intermediary compounds VI, VII and methods of their obtainment, to medicines of diabetes, obesity, atherosclerosis, hyperlipidemia treatment and prevention, containing thiazole derivative of the formula I as active component. n EFFECT: enhanced activity of derivatives. n 21 cl, 10 tbl, 102 ex |