http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2392002-C2

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filingDate 2008-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2010-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2010-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber RU-2392002-C2
titleOfInvention Tuberculosis anatoxin manufacture method
abstract FIELD: medicine. n SUBSTANCE: invention belongs to microbiology and biotechnology, notably to tuberculosis anatoxin manufacture for specific prevention of tuberculosis. Tuberculosis anatoxin is made by detoxication of tuberculosis exo- and endotoxins with two detoxifiers - 0.2% formalin solution during 7-9 days at 42-45 C° and 0.5% aethonium solution during 7-9 days at 42-45 C°. Then tuberculosis anatoxin is sorbed on 1-3 mg/ml of aluminium hydroxide, concentration of inactivated toxic allergens is doubled by decantation of 50±5% of supernatant. n EFFECT: usage of anatoxin manufactured by this method gives vaccinated animals immunity to induced by virulent tuberculosis mycobacterium infection due to immune reorganisation of organism; animals acquire moderate sensibility to tuberculin. n 4 ex
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