http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2391401-C2
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dd90155e7c0c247bbd8d22e880ed40c6 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-0783 |
filingDate | 2008-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2010-06-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_940b3be3ef67111588c821696c9a6f10 |
publicationDate | 2010-06-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | RU-2391401-C2 |
titleOfInvention | METHOD OF OBTAINING POPULATION OF HUMAN CD4+CD25+Foxp3+ T-LYMPHOCYTES ex vivo, DISEASE TREATMENT METHOD |
abstract | FIELD: chemistry; biochemistry. n SUBSTANCE: invention relates to biotechnology, in particular to obtaining cell populations of T-lymphocytes, and can be used in medicine. The method involves isolation a population of CD4+T-cells from peripheral blood of a patient and culturing the cells in a growth medium containing monoclonal antibodies to CD28 (anti-CD28) in amount of 0.5-10 mcg/ml and to CD3 (anti-CD3) in amount of 0.5-10 mcg/ml, TGF-beta 1 (1-50 ng per ml) and interleukin-2 (IL-2) in amount of 10-1000 units/ml. The obtained population of CD4+T-cells is used in a method of treating diseases characterised by pronounced reduction of amount and/or functional activity of regulatory T-cells. n EFFECT: invention enables obtaining of a population of lymphocytes rich in regulatory T-cells ex vivo. n 2 cl, 8 dwg |
isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11787866-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2670064-C2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2514653-C1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013014535-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11697688-B2 |
priorityDate | 2008-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 220.