http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2383534-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cf32b60391b469c41e86c353437f5751 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D251-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D251-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D251-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-00 |
| filingDate | 2005-06-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2010-03-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_47c6ee54620a21284faf22e6ca830209 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_75a976ca9a9ec76eb6d4cf61eb8347c8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0425a6aaea33b303923408b6b78396ba |
| publicationDate | 2010-03-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2383534-C2 |
| titleOfInvention | Enantioselective method for synthesis of quinoline derivatives |
| abstract | FIELD: chemistry. n SUBSTANCE: present invention relates to a method for synthesis of 8-phenylmethoxy-5-((R)-2-halogen-1-hydroxyethyl)-(1H)-quinolin-2-ones or their acceptable solvates, involving reaction of 5-(α-halogenacetyl)-8-phenylmethoxy-(1H)-quinolin-2-one with a reducing agent in the presence of a chiral agent and a base to form 8-phenylmethoxy-5-((R)-2-halogen-1-hydroxyethyl)-(1H)-quinolin-2-one, where the said chiral agent is characterised by formula n or , n where M represents Ru, Rh, Ir, Fe, Co or Ni, L represents C 6 -C 24 aryl or C 6 -C 24 aryl(C 1 -C 10 )aliphatic residue, in any case optionally bonded to a polymer, X represents hydrogen or halogen, R 1 represents C 1 -C 10 aliphatic, C 3 -C 10 cycloaliphatic, C 3 -C 10 cycloaliphatic(C 1 -C 10 )aliphatic, C 6 -C 24 aryl or C 6 -C 24 aryl(C 1 -C 10 )aliphatic residue to a 4-12-member heterocyclic group which is optionally bonded to a polymer in each case, and R 2 and R 3 represent phenyl, or R 2 and R 3 together with the carbon atom to which they are bonded form cyclohexane or cycloheptane. The invention also relates to a method for synthesis of salts of 5-[(R)-2-(5,6-diethylindan-2-ylamino)-l-hydroxyethyl]-8-hydroxy-(1H)-quinolin-2-one, one of the steps of is synthesis of 8-phenylmethoxy-5-((R)-2-halogen-1-hydroxyethyl)-(1H)-quinolin-2-ones. n EFFECT: design of a new cheap and highly efficient enantioselective method for synthesis of quinoline derivatives. n 10 cl, 1 tbl, 11 ex |
| priorityDate | 2004-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 235.