| abstract |
FIELD: medicine. n SUBSTANCE: method includes following stages: mixing of water with compound composition, including preparation, modifying rheology, and therapeutically active compound, for obtaining paste; extruding portion of paste for extrudate formation; spheronisation of extrudate portion for formation of spheronised particles, and drying of portion of spheronised particles. Said method includes control of water content, used in compound composition, for obtaining from 80 to 98% of particles, which have diametre from 800 to 1500 mcm. n EFFECT: possibility of application in pharmaceutics. n 25 cl, 3 dwg, 3 tbl, 8 ex |