| abstract |
FIELD: chemistry. ^ SUBSTANCE: invention relates to novel derivatives of diaryl compounds with formulae given below , ^ . ^ , in which M is S(O)2, Rx represents alkyl, R1, R2, R3 and R4 are each independently selected from OH and -NR7S(O)2R8, R5 and R7 each independently represents hydrogen or alkyl, R8 is alkyl; and their pharmaceutically acceptable derivatives, as well as to pharmaceutical compositions containing said compounds and their use in making a medicinal agent with inhibitory activity on A, IAPP amyloid fibrils or synuclein fibrils. ^ EFFECT: substituted n-arylbenzamide and related compounds for treating amyloid diseases and synucleinopathy are disclosed. ^ 11 cl, 19 ex, 6 tbl |