http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2380355-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_44e0905262f429c7590b40df8448c0c5 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C211-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C211-27 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C209-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C217-72 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C215-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C213-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C217-72 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C217-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C215-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C211-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C211-27 |
| filingDate | 2004-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2010-01-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4a21615f9bbc3f99bf84dcc4418eec89 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_377b829bf0694ab5653f71c116991360 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9c358da18b40f9be49d3b681aa99e4df http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2d979ff37f3ceda13337c24fb9e7220c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_970abb4a10a1e8d4c30eff2a1197303f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0e9c67831fb733134c420e85137e19da http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_069d09bcd277e3222f2c5492e3ff4b70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a70db11ba841dcaea899803d20c2c60a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_99ca9d25b348c0dddd8709edba24d261 |
| publicationDate | 2010-01-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2380355-C2 |
| titleOfInvention | Method of producing substituted 3-arylbutylamine compounds |
| abstract | FIELD: chemistry. ^ SUBSTANCE: invention relates to an improved method of producing substituted 3-arylbutylamine compounds of general formula I, meant for use as pharmaceutical active substances in medicinal agents and primarily suitable for pain killing. The proposed method of producing compounds of formula I in which R1 is H or branched or unbranched, saturated unsubstituted C1-C3alkyl, R2 and R3 independently represent H or branched or unbranched, saturated unsubstituted C1-C4alkyl, R4 is H or branched or unbranched, saturated unsubstituted C1-C3alkyl, R7 and R8 independently represent H or branched or unbranched, saturated unsubstituted C1-C4alkyl, R9-R13 independently represent H, OH, OR14, R14 is C1-C6alkyl, CONH-C6H5-(C1-C3alkyl), where alkyl groups in the R14 residue can be branched or unbranched, saturated unsubstituted, in each case in form of one of its pure stereoisomers, primarily enantiomers or diastereomers, its racemates or in form of a mixture of stereoisomers, primarily enantiomers of diastereomers, in any ratio in the mixture or in each case in form of a physiologically compatible salt, involves carrying out stage a) elimination of 1-amino-3-arylbutan-3-ol of general formula in which R1, R2, R3, R4, R7, R8, R9, R10, R11, R12 and R13 assume values given above, in each case possibly in form of one of its pure stereoisomers, primarily enantiomers or diastereomers, its racemates or in form of a mixture of stereoisomers, primarily enantiomers or diastereomers in any ratio in the mixture or in each case in form of a physiologically compatible salt, under the effect of the corresponding acid to obtain a substituted 3-arylbut-3-enylamine compound of general formula III, and then at second step b) the formed substituted 3-arylbut-3-enylamine compound of general formula III is hydrogenated in the presence of a palladium catalyst and hydrogen to obtain the corresponding substituted 3-arylbutylamine compound of general formula I. ^ EFFECT: method simplifies the process due to possibility of carrying out the process in a single apparatus without extraction of intermediate products with provision for enantiomeric purity during conversion of stereochemically pure compounds. ^ 90 cl, 19 ex |
| priorityDate | 2003-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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