| abstract |
FIELD: chemistry. n SUBSTANCE: invention relates to an improved method of producing 2H-1-benzopyran-2-methanol-α,α'-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-[2R*[R*[R*(S*)]]]], i.e. a nebivolol base of formula (IX), or its hydrochloride salt n n as well as to a method of producing an intermediate compound - benzylated nebivolol of formula (VIII), n n EFFECT: invention also relates to a pharmaceutical composition with antihypertensive action without using a wetting agent, and to a tablet containing this pharmaceutical composition. n 21 cl, 20 tbl, 21 ex |