| abstract |
FIELD: chemistry. ^ SUBSTANCE: present invention relates to novel hydantoin derivatives of formula or pharmaceutically acceptable salt thereof, where R1 is H, halogen, CF3 or CH2CN; R2 is C1-3alkyl; each of A, A1 and B independently represents CH or N. The invention also relates to a method for synthesis of a formula I compound, to a pharmaceutical composition based a formula I compound and use thereof in making a medicinal agent. ^ EFFECT: obtaining novel hydantoin derivatives with inhibitory activity towards metalloproteinase. ^ 10 cl, 1 tbl, 6 ex |