| abstract |
FIELD: chemistry. ^ SUBSTANCE: present invention relates to a quinazoline compound of formula or its pharmaceutically acceptable salts, used as inhibitors of potential-dependant sodium and calcium channels, where R1, R2, R3, R5a, R5, y and x are defined in the formula of invention. The invention also relates to a pharmaceutical composition containing the disclosed compound and to methods of inhibiting one or more of NaV1.2, NaV1.3, NaV1.8, or CaV2.2. ^ EFFECT: 4-aminoquinazoline antagonists of selective sodium and calcium ion channels. ^ 17 cl, 3 tbl, 1 ex |