| abstract |
FIELD: medicine. n SUBSTANCE: invention is related to new derivatives of aryl and heteroarylpiperidinecarboxylates, of formula (I): , where: type means integer numbers from 1 to 3, such that m+n is integer number from 2 to 5; p means integer number from 1 to 7; A means simple connection or is selected from one or several groups X, Y; X means -CH 2 -; Y means C 2 -alkynilene group; R 1 means group R 5 , substituted with one or several groups R 6 and/or R 7 ; R 2 means H, F, OH; R 3 means H; R 4 means H, C 1-6 -alkyl; R 5 means group selected from phenyl, pyridinyl, pyrimidinyl, pyrrolyl, imidazolyl, thiazolyl, pyrazolyl, isoxazolyl, oxadiazolyl, naphthyl, chinolynyl, tetrahydrochinolinyl, isochinolinyl, tetrahydroisochinolinyl, indolyl, indolinyl, isoindolyl, benzimidazolyl, benzoxazolyl, benzizoxazolyl, benzothiazolyl, benzithiazolyl, benzotriazolyl, benzoxadiazolyl, pyrrolopyridinyl; R 6 means halogen, CN, C 1-6 -alkyl, C 3-7 -cycloalkyl, C 1-6 -alkoxy, OH, C 1-6 -fluoroalkyl, C 1-6 -fluoroalkoxy, or cycle selected from pyrrolidine and piperidine cycle, besides this cycle is unnecessarily substituted with C 1-6 -alkyl group; R 7 means phenyl group, besides group or groups R 7 may be substituted with one or several groups R 6 , identical or differing from each other, selected from halogen, C 1-6 -alkyl and C 1-6 -fluoroalkyl, C 1-6 -alkoxy, in the form of pharmaceutically acceptable base or acid-additive salt. n EFFECT: compounds are applicable as inhibitors of FAAH ferment. n 10 cl, 1 tbl, 7 ex |