| abstract |
FIELD: chemistry. n SUBSTANCE: in compounds of formula (I) , Q is: (IIa) or (IIb) , R 1 is chosen from a group which consists of carboxylic aryl and carboxylic aryl which is substituted with substitute(s) independently chosen from a group which consists of halogen, cyano, nitro, C 1-10 alkyl, C 1-10 alkyl which is substituted with substitute(s) independently chosen from a group which consists of halogen, C 1-9 alkoxy, C 1-9 alkoxy which is substituted with substitute(s) independently chosen from a group which consists of halogen, mono-C 1-5 alkylamino, and heterocyclyl or heterocyclyl which is substituted with substitute(s) independently chosen from a group which consists of halogen, C 1-5 alkyl; R 2 is C 1-5 alkyl, C 1-5 alkyl which is substituted with halogen, C 1-5 alkyl which is substituted with carboxylic aryl, C 1-5 alkoxy, -N(R 2a )(R 2b ); where R 2a and R 2b are each independently hydrogen, C 1-5 alkyl or C 1-5 alkyl, substituted with substitute(s) independently chosen from a group which consists of hydroxyl, carboxylic aryl; L represents formula (IIIa); , where R 3 and R 4 are each hydrogen; A is a single bond, and B is a single bond or -CH 2 -; Z 1 , Z 3 , and Z 4 are each independently hydrogen, halogen, C 1-5 alkyl, C 1-5 alkyl, substituted with carboxylic aryl, C 1-5 alkoxy, mono-C 1-5 alkylamino, di-C 1-5 alkylamino, carboxylic aryl, heterocyclyl or substituted heterocyclyl; Z 2 is hydrogen, C 1-5 alkyl, C 1-5 alkyl which is substituted with carboxylic aryl, C 1-5 alkoxy, mono-C 1-5 alkylamino, di-C 1-5 alkylamino, carboxylic aryl, heterocyclyl or substituted heterocyclyl; Y is -C(O)NH-, -C(O)-, -C(S)NH-, -C(O)O- or -CH 2 -; where carboxylic aryl is phenyl; heterocyclyl is 1H-indolyl, 9H- xanthenyl, benzo[1,3]dioxolyl, furyl, imidazolyl, isoxazolyl, morpholinyl, piperazinyl, pyridyl, pyrrolidyl; halogen is fluorine, chlorine, bromine or iodine. The invention also relates to a pharmaceutical composition. n EFFECT: compounds can be used for treating central nervous system diseases, and for improving memory functioning, sleep, awakening, diabetes. n 16 cl, 8 dwg, 4 tbl, 525 ex |