| abstract |
FIELD: medicine. n SUBSTANCE: according to the invention there is provided substituted indolequinoxalines of the formula (I), where R 1 represents hydrogen or represents one or more similar or different substituent in positions from 7 to 10, selected of the group of halogen, low alkyl/alkoxy, hydroxy, triflouromethyl, trichloromethyl, triflouromethoxy, R 2 represents similar or different C 1 -C 4 alkyl substituents, X represents CO or CH 2 , Y represents OH, NH 2 , NH-(CH 2 ) n -R 3 , where R 3 represents low alkyl, OH, NH 2 , NHR 4 or NR 5 R 6 , where R 4 , R 5 and R 6 represent low alkyl or cycloalkyl independently and n represents integer from 2 to 4 provided that X represents CH 2 , Y represents OH or NH-(CH 2 ) n -OH and its pharmaceutically acceptable salt. There is also provided pharmaceutical composition, containing these compounds, methods of compound producing, formula (I). n EFFECT: compounds are applied as medicine for treatment and prevention of autoimmune diseases. n 15 cl, 1 ex, 5 dwg |