| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_34ff9b0940eaaa88c3d87928b1fabeae |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-88 |
| filingDate |
2006-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2009-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b5b3ad4133ed39cf7927f47895ea8418
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_97a8b771bd41d8e7230599c33053be65
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_92d3ccdbdc031b8787d7b44b3f3a300c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c3f4c05bcfa40f11027861053a1a9420
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ad02072e733316c840c89e83f17aed98
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_915d92be77454b2f1aa92f003ff28931
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_66436f777549b54ff79592c50e575c99
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_01c96b352859810e1b28fae0d5bd5202
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2dda1571bb6cd5ca9be8989a8d598918
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d295e94e17e6c15ff77a8e7490a62c31
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c39b168f9592c1a1fc44ebdddf781ff3 |
| publicationDate |
2009-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
RU-2366653-C2 |
| titleOfInvention |
Method for preparation of x-ray amorphous carvedilol modification |
| abstract |
FIELD: chemistry. n SUBSTANCE: invention refers to the methods for preparation of X-ray amorphous carvedilol [(+)-1-(9H-carbazole-4-yloxy)-3-{[2-(2-methoxyphenoxy)ethyl]amine}propane-2-ol] modification and can be used in pharmaceutical industry. Method involves the evaporation of carvedilol parent drug in vacuum device at temperature 80-200 o C, residual pressure 5 - 5×10 -4 Torr in a inert gas flow fed with the rate from 10 to 100 ml/min with following condensation at -196 - +25 o C. The process results in obtaining of powder of X-ray amorphous carvedilol [(±)-1-(9H-carbazole-4-yloxy)-3-{[2-(2-methoxyphenoxy)ethyl]amine}propane-2-ol] modification with particle size less than 5 mcm. n EFFECT: enhancing of bioactivity. n 7 ex, 8 dwg |
| priorityDate |
2006-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |