http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2355703-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ae7eb7b04fe96af2c3e109364ab8e52c |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-63 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-725 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12 |
| filingDate | 2003-10-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2009-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3a6ddc945bf48b9917e13317adfcc0f6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a202b9a42d5db0c27623f8cad49bba04 |
| publicationDate | 2009-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2355703-C2 |
| titleOfInvention | Single-strand recombinant t-cell receptors |
| abstract | FIELD: biotechnology. n SUBSTANCE: present invention relates to biotechnology. Description is given of a single-strand T-cell receptor (scTCR), containing an α segment, formed by a sequence of a variable region in a TCR chain, joined with the N end of the extracellular sequence with constant region in the TCR chain, a β segment, formed by a sequence of the variable region of the α TCR chain, joined with the N end of the extracellular sequence with constant region of the β TCR chain, and a linker sequence, joining the C end of the α segment with the N end of the β segment, or vice versa. Extracellular sequences of constant regions of α and β segments are joined by a disulphide bond. Extracellular sequences of constant regions can correspond to constant regions of α and β chains of native TCR, cut-off at their C ends such that, cysteic residues, which form the inter-chain native disulphide bond of the TCR, are excluded, or extracellular sequences of constant regions which are in the α and β segments, can correspond to constant regions of α and β chains of native TCR, in which cysteic residues, which form the native inter-chain disulphide bond, are replaced by another amino acid residue, or there is no uncoupled cysteic residue, which is in the β chain of the native TCR. This invention makes available a new class of alpha/beta analogues of scTCR, in which there is a disulphide bond between residues of a single amino acid, contributing to stability of the bond between the alpha and beta regions of the molecule. n EFFECT: such TCR are suitable for screening or for therapeutic purposes. n 3 cl, 14 dwg, 3 ex |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2569186-C2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11286289-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11434293-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11572400-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11725040-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2775394-C2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2791327-C2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2744046-C2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11440961-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2645256-C2 |
| priorityDate | 2002-10-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 154.