http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2352582-C2

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filingDate 2003-01-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2009-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bbe05c437d3887901fff765ee79e6ef6
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publicationDate 2009-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber RU-2352582-C2
titleOfInvention Conjugates containing antibody, specific for ed-b-domain of fibronectin, and their application for detection and treatment of tumours
abstract FIELD: medicine. n SUBSTANCE: versions of the bond intended for linkage with the external domain B (ED-B) of a fibronectin are offered. The bond includes an antigen-binding fragment of one-chained antibody L19 and a cysteinum-containing linker for hanging of a radioactive label. Versions of a pharmaceutical composition for diagnostics and treatment of angiogenic diseases on the basis of the specified bond are opened. Application of bond for linkage with radioactive bond is described. The method of reception of bond in eucariotic cells is opened, including in Pichia pastoris and a set for reception is radioactive labelled agents on the basis of bond. n EFFECT: high-avid bond accumulation in solid tumours. n 23 cl, 4 dwg, 5 tbl, 15 ex
priorityDate 2002-01-03-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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