| abstract |
FIELD: chemistry. n SUBSTANCE: invention relates to novel compounds of formula (I), including its pharmaceutically acceptable salts, solvates, ethers and amides, possessing ability to bind ERα- and ERβ-estrogen receptors, to pharmaceutical composition based on them, to versions of applying claimed compounds in medication preparation and to method of binding ERα- and ERβ-estrogen receptors. (I), where R 1 represents H, OH or C 1-12 alkoxy, or halogen; R 2 represents H, OH or halogen; R 3 represents C 1-12 alkyl, halogeno-C 1-12 alkyl, C 3-10 cycloalkyl, C 1-12 alkoxy or C 1-12 alkoxyC 1-12 alkyl; R 4 represents H or C 1-12 alkoxy; R 5 represents H, halogen or halogeno-C 1-12 alkyl; R 6 represents -(Y) z -R 7 ; R 8 represents phenyl or 5- or 6-member heteroaryl, containing N, O or S as heteroatom, where said phenyl and heteroaryl are possibly substituted with OH, halogeno, halogenoC 1-12 alkyl or C 1-12 alkoxy. Values R 7 , Y and z are presented in invention formula. n EFFECT: novel compounds possess useful biological properties. n 19 cl, 7 dwg, 1 tbl, 70 ex |