| abstract |
FIELD: chemistry. n SUBSTANCE: present invention pertains to new compounds with formula (I): where R 1 and R 2 each independently represents a hydrogen atom, C1-8 alkyl or a halogen atom; R 3 represents C1-8 alkyl, which can be substituted with 1-3 halogen atom(s) or phenyl; R 4 represents a hydrogen atom or C1-8 alkyl; R 5 and R 6 each independently represents a hydrogen atom; X represents a sulphur atom or oxygen atom; ring A is 4-(trifluoromethyl)piperidin-1-yl, 2,2-difluoro-1,3- benzodioxol-5-yl or 3,4-dihydro-1H-isoquinolin-2-yl. The invention also relates to salts or solvates of this derivative, as well as medicinal preparation, pharmaceutical composition, method of preventing and/or treating diseases, caused by PPAR, and use of this derivative. n EFFECT: obtaining new biologically active compounds, which can be used for preventing and/or treating diseases caused by PPARĪ“. n 8 cl, 39 ex, 2 tbl |