| abstract |
FIELD: chemistry. n SUBSTANCE: invention claims compound of the general formula (I) , where R is hydrogen atom or vinyl group; n is 1, X is a group of the formula CH or nitrogen atom, R 1 is either phenyl or naphthyl group, or cyclohexyl group, or heteroaryl group, R 2 is either hydrogen atom or one or more substitutes selected out of halogen atoms and trifluoromethyl, alkyl, alkoxyl phenyloxy, hydroxyl groups or group of the general formula -NR 4 R 5 , SO 2 NR 4 R 5 , or group of the formula -OCF 2 O-, each of R 4 and R 5 groups is hydrogen atom or alkyl group; and method of obtaining compound of the general formula (I), medicine, pharmaceutical composition. Compounds display special effect as specific inhibitors of glycine GlyT1 and/or GlyT2 transmitters and thus are applied in treatment of various diseases. n EFFECT: obtaining compounds with high specific inhibition effect. n 13 cl, 2 tbl, 5 ex |