http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2346004-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4e1cfee94c7d17bc35f54f303aef6a5c |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705 |
| filingDate | 2003-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2009-02-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c2c12c26d6727dcc7208ed9ce90e658d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1de1cd8c050d53cc0e396feb2431c32b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_174a680049f661b2f80b1d49bd2bf559 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b0a8c39848c4ef2fdebfe97e171e3023 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b7272d81bbdd0c1279fd4ffb83c793d7 |
| publicationDate | 2009-02-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2346004-C2 |
| titleOfInvention | Exposure of t-cell receptors |
| abstract | FIELD: chemistry; biochemistry. n SUBSTANCE: present invention pertains to biotechnology. Description is given of a phage particle, exposing on its surface, T-cell receptor (TCR), which is a human scTCR. The exposed dTCR polypeptide pair or exposed scTCR polypeptide contains a series of α and β chains of extra-cellular constant lg of the native TCR domain. A disulphide bond joins amino acid residues of the given series of chains of the constant lg domain, where the given disulphide bond is between cysteic residues. Presented is a library of polypeptide pairs of mutated TCR or scTCR polypeptides, exposed on the described phage particle. Nucleic acid, which encodes the described phage particle, is also presented. A method of identifying TCRs is invented. The invention can be used for making various TCR libraries, for identification of high-affinity TCRs. n EFFECT: possibility of making various TCR libraries for identification of high-affinity TCRs. n 17 cl, 25 ex, 63 dwg, 2 tbl |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2678421-C2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10370651-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2777769-C2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11414784-B2 |
| priorityDate | 2002-11-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 134.