http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2345989-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0a910d33c239980f3a705e312c5bad6a |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-517 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-056 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-94 |
| filingDate | 2003-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2009-02-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d6d566d36983a73294aecb365e12956d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4e775866d47706323733d0e85dcec355 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9331bfa2e5124860a8411a80d4116057 |
| publicationDate | 2009-02-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2345989-C2 |
| titleOfInvention | Derivatives of 4-anilino-benzodiazine, method of obtaining them (versions) pharmaceutical composition, method of inhibiting their proliferative action and method of treating cancer in warm-blooded animal |
| abstract | FIELD: chemistry. n SUBSTANCE: invention relates to new derivatives of benzodiazine of the formula (1), which possess properties of inhibiting proliferative action and can be used during treatment of hyper-proliferative diseases like cancer. In formula (I) G 1 and G 2 each independently representing a halogen; X 1 -R 1 selected C 1 -C 6 -alkoxy, X 2 represents a simple bond; Q 1 represents a non-aromatic saturated 3-7-member monocyclic heterocyclic ring with 1 circular heteroatom of nitrogen and not necessarily 1 or 2 heteroatoms, selected from nitrogen, oxygen and sulphur, where Q 1 does not necessarily have 1, 2 or 3 substitute groups, which can be similar or different , selected from cyano, carbamoyl, C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, C 1 -C 6 -alkylthio, C 1 -C 6 -alkyl-sulfinyl C 1 -C 6 -alkyl-sulfonyl, N-C 1 -C 6 -alkyl-carbamoyl N,N-di-[C 1 -C 6 -alkyl]carbamoyl, C 1 -C 6 -alkanoyl, sulfamoyl, N-C 1 -C 6 -alkyl-sulfamoyl, N,N-di-[C 1 -C 6 -alkyl-]sulfamoyl, carbamoyl C 1 -C 6 -alkyl, N-C 1 -C 6 -alkyl-carbamoylC 1 -C 6 -alkyl, N,N-di-[C 1 -C 6 -alkyl]carbamoylC 1 -C 6 -alkyl, sulfamoylC 1 -C 6 -alkyl, N-C 1 -C 6 -alkyl-sulfamoylC 1 -C 6 -alkyl, N,N-di-[C 1 -C 6 -alkyl]sulfamoylC 1 -C 6 -alkyl, C 1 -C 6 -alkanoylC 1 -C 6 -alkyl, or from the group with the formula: Q 2 -X 3 -, where X 3 represents CO and Q 2 represents a non-aromatic saturated 3-7-member monocyclic heterocyclic ring with 1 circular nitrogen heteroatom and not necessarily 1 or 2 heteroatoms, selected from nitrogen and sulphur, and where. Q 2 does not necessarily have 1, 2 or 3 substitute groups, which can be similar or different, selected from halogens, C 1 -C 4 -alkyl, and where any C 1 -C 6 -alkyl and C 2 -C 6 -alkaloid groups within the limits of Q 1 does not necessarily have one or more substitute groups, which can be similar or different, selected from hydroxy and C 1 -C 6 -alkyl and/or not necessarily a substitute selected from cyano, C 1 -C 6 -alkoxy, C 2 -C 6 -alkanoxy and NR a R b , where R a represents hydrogen or C 1 -C 4 -alkyl and R b represents hydrogen or C 1 -C 4 -alkyl, or R a and R b together with a nitrogen atom, to which they are attached, they form a 4-, 5- or 6- member non-aromatic saturated monocyclic heterocyclic ring with 1 circular heteroatom of nitrogen and not necessarily 1 or 2 heteroatoms, selected from nitrogen, oxygen and sulphur, which not necessarily have 1 or 2 substitutes, which can be similar or different, on the available carbon atom, and selected from halogens and C 1 -C 3 -alkilenedioxy. n EFFECT: obtaining new derivatives benzodiazine, which possess properties of inhibiting proliferative action and can be used during the treatment of hyper-proliferative diseases such as cancer n 27 cl, 73 ex |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2641001-C1 |
| priorityDate | 2002-03-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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