| abstract |
FIELD: chemistry, pharmacology. n SUBSTANCE: claimed invention relates to fluorine and trifluoralkyl-containing heterocyclic sulfonamides of general formula I , where T - CHO, COR 8 and C(OH)R 1 R 2 ; R 1 and R 2 -hydrogen, C 1-6 alkyl; R 3 -hydrogen; R 4 - (CF 3 ) n alkyl, (CF 3 ) n alkylphenyl, and (F) n cycloalkyl; N equals 1-2; R 5 - hydrogen, halogen, dien, condensed with Y, when Y stands for C, and dien, condensed with Y, when Y stands for C and substituted with halogen; W, Y and Z - C, CR 6 and N, on condition that at least one of W or Y, or Z must be C; R 6 -hydrogen halogen or C 1-6 alkyl; X - S and NR 7 ; R 7 - C 1-6 alkyl; and R 8 - C 1-6 alkyl. Also described are method of obtaining compounds I, pharmaceutical composition and application of compounds, intermediate compounds, used in synthesis. n EFFECT: obtaining compounds which can be used to inhibit beta-amyloid formation and for treatment of Alzheimer's disease. n 48 cl, 5 tbl, 42 ex |