http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2336277-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_019d4481a09e99aa635a15f4d07f44a8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H15-252 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H1-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-252 |
| filingDate | 2004-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2008-10-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_168005e3eedccfc32ebedfc536c7aac2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dc22863fb1d96b15c3346e1d3aa24e86 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e540dc5802a8b5f28c8f8af0085a42b6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6bdbfd918213205408db2018b7fdb4a6 |
| publicationDate | 2008-10-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2336277-C2 |
| titleOfInvention | Method of obtaining 4-r-substituted 4-demethoxydaunorubicin |
| abstract | FIELD: chemistry. n SUBSTANCE: invention relates to improved method of obtaining 4-R-substituted anthracyclines of formula (I) , and their corresponding salts from 4-demethyldaunorubicin. Steps of treating 4-demethyldaunorubicin with a sulfonylating agent to form 4-demethyl-4-sulfonyl-R 3 -daunorubicin. 4-Demethyl-4-R 3 -sulfonyl-daunorubicin are performed, then it is processed with reducing agent in the presence of a transition metal catalyst in a temperature range from 30°C to 100°C in polar aprotic solvent in an inert atmosphere. Protected 4-demethoxy-4-R-daunomycin then undergoes hydrolysis in a basic solution to form the 4-R-substituted anthracyclines. Application of novel method makes it possible to avoid stage of forming stereospecific glycoside bond between aglycone and aminoglycoside. The method also increases the yield of final product up to 30-40%. n EFFECT: elaboration of efficient method of obtaining 4-R-substituted demethyldaunorubicin. n 13 cl, 10 ex |
| priorityDate | 2003-05-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 84.