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publicationDate 2008-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber RU-2333905-C2
titleOfInvention Method of purification of tiosemicarbazone guanylhydrbazone 1,4-benzohinon (ambazone)
abstract FIELD: chemistry. n SUBSTANCE: method of purification of tiosemicarbazone guanylhydrazone 1,4-benzochinon(ambazone), according to which subjected to purification is non-purified ambazone, includes stage of sulfur extraction, present in non-purified ambazone with non-polar solvents, such as benzole, n-hexane, toluol or xylol, with ratio ambazone:solvent equal to 1:(1-5) (weight/vol.) at temperatures within the range of 20-60°C, filtration and further second stage of purification with addition of solvent mixture, which consists of N,N-dimethylformamide and lower aliphatic alcohols (C 1 -C 4 ) with ratio ambazone : N,N-dimethylformamide : lower aliphatic alkohol equal to 1:(1-3):(2-5) (weight/vol/vol)) at temperatures within the range of 50-80°C, with obtaining pure product. Ambazone is used as active start for obtaining medication FARINGOSEPT. n EFFECT: obtaining product of high quality directly from non-purified ambazone without sulfur. n 3 ex
priorityDate 2003-09-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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