abstract |
FIELD: chemistry. n SUBSTANCE: invention concerns malonamide derivatives of the formulae (IA) or (IB) , and pharmaceutically acceptable acid additive salts of them, where R 1 , R 1 ',(R 2 ) 1,2,3 , R 3 , R 4 , R 14 , L, and are such as described in this invention. Also the invention concerns a medicine with inhibition effect on γ-secretase, which can be applied in treatment of Alzheimer's disease. n EFFECT: obtaining new malonamide derivatives with beneficial biological properties. n 17 cl, 188 ex |