http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2329264-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a7f82940e47ba7a1188f8e2ffca55e0f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-443 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 |
| filingDate | 2003-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2008-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3b34fcf768ee204570a478fdbd345523 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1d9bc70549381147ecbf2033f436b9af http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e619ccaef5988664d0ed2fae4fb69ba5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e924b7f1db6fe0ff1963f56ce6ea3b02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_07e0c108a14072e592b12ad603a9c4c9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_464b36d9c62b30759ecac54661ea5423 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ed20f97f0f309397e5fb9d1ab27ae4b1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2fb8a16f8902de7ddbbffbd6eaeaae51 |
| publicationDate | 2008-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2329264-C2 |
| titleOfInvention | Tricyclic antagonists of thrombin receptors |
| abstract | FIELD: chemistry. n SUBSTANCE: tricyclic bonds are substituted with heterocyclic ones, which have the formula (I), or its pharmaceutically acceptable salt or solvate in which: n denotes 0-2; Q denotes , R 1 denotes H, R 2 represents H or alkyl with 1-6 carbon atoms, R 3 represents H, hydroxy-group, -NR 22 R 23 , Het denotes mono- or bycyclic heteroaryl group from 5 - 10 atoms, containing from 1 to 9 carbon atoms and 1 heteroatom N, where Het bonds with B through the cyclic carbon atom, and the group Het has a substitute W. W consists of from 1 to 4 substitutes, independently selected from the group containing H, halogen, R 21 -aryl and P 21 -heteroaryl, R 4 and R 5 are independently selected from the group containing H and alkyl with 1 - 6 carbon atoms, R 7 , R 8 , R 10 and R 11 denote R 1 , R 9 represent H, B represents -(CH 2 ) n3 -. cis- or trans -(CH 2 ) n4 CR 12 =CR 12a (CH 2 ) n5 or -(CH 2 ) n4 C=C(CH 2 ) n5 , where n 3 denotes 0-5, n 4 and n 5 independently denote 0-2, and R 12 and R 12a denote H, X represents -O-, Y represents =O, each R 13 is independently selected from the group containing H, alkyl with 1-6 carbon atoms, -(CH 2 ) n6 NHC(O)OR 16b , -(CH 2 ) n6 NHC(O)R 16b , -(CH 2 ) n6 NHC(O)NR 4 R 5 , -(CH 2 ) n6 NHSO 2 R 16 , and -(CH 2 ) n6 C(O)NR 28 R 29 , where n 6 denotes 0, each R 14 is independently selected from the group containing H, alkyl with 1-6 carbon atoms, -(CH 2 ) n6 NHC(O)OR 16b , -(CH 2 ) n6 NHC(O)R 16b , -(CH 2 ) n6 NHC(O)NR 4 R 5 , -(CH 2 ) n6 NHSO 2 R 16 and -(CH 2 ) n6 C(O)NR 28 R 29 , where n 6 denotes 0, where, at least one of R 13 and R 14 is chosen from the group containing -(CH 2 ) n6 NHC(O)OR 16b , -(CH 2 ) n6 NHC(O)R 16b , -(CH 2 ) n6 NHC(O)NR 4 R 5 , -(CH 2 ) n6 NHSO 2 R 16 and -(CH 2 ) n6 C(O)NR 28 R 29 , where n 6 denotes 0, R 16 represents an alkyl with 1-6 carbon atoms, R 16b represents H, an alkyl with 1-6 carbonatoms, (an alkoxy with 1-6 carbon atoms)-(an alkyl with 1 - 6 carbon atoms)-, R 22 -O-C(O)-(an alkyl with 1 - 6 carbon atoms)-, a cycloalkyl with 3-6 carbon atoms, R 21 represents from 1 to 3 substitutes, which are independently selected from a group comprising of H, -CN, -CF 3 , halogen, alkyl with 1 - 6 carbon atoms, -OH, alkoxy- group with 1 - 6 carbon atoms, -C(O)NR 25 R 26 and -SR 13 , R 22 represents H or an alkyl with 1-6 carbon atoms, R 23 represents H, R 25 and R 26 are independently selected from a group comprising of H and an alkyl with 1 - 6 carbon atoms, and R 28 and R 29 are independently selected from a group comprising of H, an alkyl with 1 - 6 carbon atoms, heteroaryl, heterocyclil and also a pharmaceutical composition, containing these bonds. n EFFECT: application for getting medication for the treatment of diseases related to thrombosis, atherosclerosis, restenosis, hypertension, sternocardia, arrythmia, cardiac insufficiency and cancer, the way of administering is specified in the bonds Also therapy in combination with other cardiovascular agents is allowed. n 23 cl, 7 tbl, 92 ex |
| priorityDate | 2002-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 219.