| abstract |
FIELD: chemistry. n SUBSTANCE: invention relates to producing the novel compounds with dipeptidyl peptidase IV (DPP-IV) inhibiting activity and particularly, it relates to the compounds with the condensed 1,3-dihydroimidazole cycle. The invention relates to the compounds represented by the common formula (II), or their pharmaceutically acceptable salts, where, Z 3a means nitrogen atom or the group with formula -CR 2a=; X 3a means oxygen atom or sulfur atom; T 1a means piperazine-1-yl group, 3-amino-piperidine-1-yl group, 3-methylamino-piperidine-1-yl group; X 1a means oxygen atom hydrogen, C 2-6 -alkenyl group, C 2-6 -alkynyl group or benzyl group; each of R 1a and R 2a independently means hydrogen atom, halogenatom, C 1-6 -alkyl group, cyanogroup or group, represented with formula-A 0a -A 1a ; A 0a means oxygen atom, sulfur atom or group, represented with formula-NA 2a- ; A la means hydrogen atom, C 1-6 -alkyl group, C 1-6 -alkenyl group, C 2-6 -alkynyl group, phenyl group, cyanophenyl group, carbamoylphenyl group, benzyl group; A 2a means hydrogen atom or C 1-6 -alkyl group; X 2a means hydrogen atom, C 2-6 -alkenyl group, C 2-6 -alkynyl group, 1H-piridine-2-onyl group, 1-methyl-1H-piridine-2-onyl group, C 1-6 -alkyl group, which can have a group, selected from the substitutes group specified below B, phenyl group, which can have a group, selected from the substitutes group specified below B, 5- or 6-membered heteroarylgroup, containing one or two nitrogen atoms, oxygen or sulfur, which can have a group, selected from the substitutes group specified below B, phenylC 1-6 -alkyl group, which can have a group, selected from the substitutes group specified below B: <Substitutes group B> substitutes group B is group, including chlorine atom, bromine atom; cyanogroup, C 1 -b-alkyl group, C 2 -b-alkenyl group, C 2-6 -alkynyl group, C 3-8 -cycloalkyl group, C 1-6 alcoxigroup, carbamoyl groupcarboxyl group and C 1-6 -alcoxicarbonyl group. n EFFECT: research and revealing compounds with DPP-IV inhibiting activity, useful as pharmaceutical agents which can be used as therapeutic and preventing medicines in such diseases as diabetes, obesity and hyperlipidemia. n 12 cl, 84 ex, 2 tbl |