| abstract |
FIELD: chemistry. n SUBSTANCE: invention relates to the novel indole derivatives with the formula , where X means S, SO, SO 2 ; R 1 means 6-membered mono-homocyclic saturated or unsaturated ring structure or 5-, 6-membered monohetercyclic saturated or unsaturated ring structure with one or two heteratoms, chosen from N, O, S, and each of the said structures is not necessarily substituted with one or more substituters, chosen from the group, consisting of halogen, CN, (1C-4C)fluoroalkyl, NO 2 , (1C-4C)alkyl, (1C-4C)alkoxi or (1C-4C)fluoroalkoxi; R 2 means 2-nitorphenyl, 2-cyanophenyl, 2-hydroxymethylphenyl, pyridine-2-il, pyridine-2-il-N-oxide, 2-benzamide, methylic ether of the 2-benzoic acid or 2-methoxyphenyl; R 3 means H, halogen or (1C-4C)alkyl; R 4 means H, OH, (1C-4C) alkoxy or halogen; R 5 means H, OH, (1C-4C) alkoxy, NH 2 CN, halogen, (1C-4C)fluoroalkyl, NO 2 , hydroxy(1C-4C)alkyl, CO 2 H, CO 2 (1C-6C)alkyl, or R 5 means NHR 6 , where R 6 means (1C-6C)acyl, not necessarily substituted with one or more halogens, S(O) 2 (1C-4C)alkyl or S(O) 2 heteroaryl, not necessarily substituted with (1C-4C)alkyl or one or more halogens, where heteroaryl is the 5-membered mono-heterocyclic unsaturated ring structure with one S atom or two N atoms, or R 5 means C(O)N(R 8 ,R 9 ), where R 8 and R 9 , each independently, mean H, (3C-6C)cycloalkyl or CH 2 R 10 , where R 10 means H, (1C-5C)alkyl, hydroxy(1C-3C)alkyl, complex (1C-4C)alkyl ether of the carboxy(1C-4C)alkyl, (1C-3C)alkoxy(1C-3C)alkyl, (mono- or di(1C-4C)alkyl)aminomethyl, (mono- or di1C-4C)alkyl)aminocarbonyl or pyhenyl, where R 8 and R 9 together with N form 5- or 6-membered saturated aor unsaturated heterocyclic ring, not necessarily containing N or O as the second heteroatom, not necessarily substituted with (1C-4C)alkyl; or its saline or hydrated form. n EFFECT: allows using indoles for producing pharmaceutical agent and in method for inhibiting 5α-dihydrosterone activity. n 17 cl, 7 dwg, 5 tbl, 25 ex |