abstract |
FIELD: chemistry. n SUBSTANCE: invention pertains to new hetero-aryl derivatives of 8-azabicyclo-[3.2.1]-octan-3-ol with general formula I where R-R 4 represent hetero-aryl. The hetero-aryl is in form of a cyclic aromatic group with C5-C6 or a bicyclic group with C9-C10, which contain 1, 2 or 3 hetero atoms, independently O, S or N, or a residue of , R 1 -H, C 1 -C 6 -akyl, R 2 and R 3 independently CH 3 , -OCH 3 , F, Cl, Br, J, R 4 - from 1 to 4 substitutes, -H, halogen, C 1 -C 6 alkyl, -CF 3 , -OCF 3 , -(CH 2 ) n -OR 5 , -(CH 2 ) n -NR 5 R 6 , -(CH 2 ) n -NHSO 2 R 5 , -(CH 2 ) n -NH(CH 2 ) 2 NR 5 R 6 , -(CH 2 ) n -NHC(O)NR 5 R 7 , -(CH 2 ) n -NH(CH 2 ) 2 OR 5 , or 1-piperazinyl; n - 0, 1, 2, 3; R 5 and R 6 - H, C 1 C 3 alkyl, R 7 -H, C 1 -C 3 alkyl, aminoalkyl C 1 -C 3 , or to their pharmaceutical salts. The compounds are antagonists of the nociceptin ORL-1 receptor. n EFFECT: obtaining of compounds that are useful in the treatment of cough. n 10 cl, 22 ex, 1 tbl |