| abstract |
FIELD: chemistry. n SUBSTANCE: invention pertains to tricyclic derivatives, represented by formula (I) or to their pharmaceutical salts, which have proliferative activity and ability to inhibit angiogenesis, to the method of obtaining them (alternatives), the proliferative agent and an angiogenesis inhibitor on their base. , where R 1 represents T 1 B 1 ; Ti represents -N(R 5 )C(O)-, where R 5 represents H or C 1 -C 5 alkyl group; and B 1 is chosen from a group, consisting of the following values (a),(b),(f),(g): , where represents , or ; R 6 represents H, halogen or hydroxy group; R 7 represents a hydroxy or -ONO 2 group, under the condition that R 6 represents H, R 7 is different from hydroxyl; T 2 represents -O-C(O)-; B 2 the stated (a) group or -Z 1 -R 7 , where Z 1 represents a linear C 2 -C 5 alkyl group, n 2 represents an integer 0-3; and n 3 represents an integer 0-5; R 2 represents CH 3 ; R 3 represents C 1- C 4 unbranched or branched alkyl, or C 3 -C 7 cycloalkyl, under the condition that, if B 1 represents (a), R 6 represents H, R 7 represents an -ONO 2 group and R 3 is not CH 3 ; R 4 represents SCH 3 or OCH 3 ; X represents O. n EFFECT: perfection of the method of obtaining compounds. n 7 cl, 6 tbl, 14 dwg, 48 ex |