| abstract |
FIELD: chemical-pharmaceutical industry. n SUBSTANCE: invention covers preparation of oral formulations of medicines possessing the neuroprotective activity, particularly, Memantine, the modulator of the glutamatergic system which is used in treatment of dementia, memory impairment, cerebral and spinal spastic syndrome. The therapeutically effective amount of Memantine is prepared as a capsule dosage form containing the mixture of powders or granulated material. The encapsulated substance contains the additional auxiliary substances: the physiologically neutral filler and a disintegrator and antifriction substance. The method of preparation of pharmaceutical composition consists in sifting, weighing and mixing the powders of Memantine and auxiliary substances at specified mass proportions with following filling the capsule with the powder mixture or granulated material obtained by dry or humid pelleting, from the powder mixture. n EFFECT: invented formulation has bioavailability higher than tablets; it has prospects for using in pediatrics and gerontology while preparation cost is reduced. n 14 cl, 4 ex |