| abstract |
FIELD: chemistry. n SUBSTANCE: invention relates to new derivatives of benzimidazol of the general formula I R 1 designates phenyl group which unessentially contains up to three substitutors independently chosen of the group including F, Cl, Br, J, R 4 ; R 2 designates monocyclic or bicyclic 5-10-terms heteroaryl group which contains 1-2 heteroatoms, chosen of N, S and O; R 3 designates H; R 4 designates C 1-6 alkyl; A designates C 2-6 alkylene group; B designates group COOH, CONH 2 , CONHR 5 or CONR 5 R 5 , in each case attached to atom of carbon of group A; R5 and R5 ' independently designate the residue chosen from group including C 1-6 alkyl where one C-atom can be replaced by O, and (C 0-3 alkandiil-C 3-7 cycloalkyl); and to their pharmaceutically acceptable salts, except for following compounds: 6 [[1-phenyl-2 (pyridine-4-il)-1H-benzimidazol-6-il] oxi] hexanic acid and 6 [[1-phenyl-2 (benzothien-2-il)-1H-benzimidazol-6-il] oxi] hexanic acid. The invention relates also to pharmaceuticals and to application of compounds of general formula I. n EFFECT: new biologically active compounds possess inhibiting effect on activation of microglia. n 10 cl, 34 ex |