http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2324686-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d48a0d41804d522c5ad16e793372520b |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-05 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0497 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-428 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5415 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-66 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K101-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-428 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B59-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-10 |
| filingDate | 2001-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2008-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c532de471b52acb26d3d2e29e1619ac6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_057052c7a902fa367707c9fec4c66618 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_df17ec7d546ae1117a3bcf6314931f2f |
| publicationDate | 2008-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2324686-C2 |
| titleOfInvention | AMYLOID-BINDING THIOFLAVIN DERIVATIVES, METHOD OF in vivo DETECTION OF AMYLOID DEPOSIT AND METHOD OF DIAGNOSTICS OF ALZHEIMER'S DISEASE |
| abstract | FIELD: medicine; pharmacology. n SUBSTANCE: invention relates to the amyloid-binding compound or its water-soluble non-toxic salt, where Y is presented by NR 1 R 2 ; Z means S; R 1 is chosen from group consisting of H, methyl, propyl, (CH 2 ) n OR' (where n = 1, 2 or 3 and R' is presented by H or by lowest alkyl group), CF 3 , CH 2 -CH 2 X, CH 2 -CH 2 -CH 2 X (where X = F, Cl, Br or I); where R 2 is chosen from group consisting of lowest alkyl group, (CH 2 ) n OR' (where n = 1, 2 or 3 and R' is presented by H or by lowest alkyl group), CF 3 , CH 2 -CH 2 X, CH 2 -CH 2 -CH 2 X (where X = F, Cl, Br or I); R 3 - R 10 are chosen independently from group, consisting of H, F, CI, Br, I, lowest alkyl group, (CH 2 ) n OR' (where n = 1, 2 or 3) or OR' , and R' means H lowest alkyl group); provided, the compound isn't related one of the following compounds: methyl-[4-(6- methyl -benzothiazole-2-il)phenyl]amin, dimethyl -[4-(6- methyl - benzothiazole-2-il)phenyl]amin, and where at least one of R 1 -R 10 substitutors contains the radioactive marker, chosen from group, which consists of 11 C, 123 I, 125 I or 127 I, and the described compounds don't contain the nitrogen quaternary atoms. The invented compounds are used for detection of the amyloid deposit in patient and in differential diagnostics of brain affected by Alzhemer's disease and normal brain. . n EFFECT: thioflavin derivatives are obtained for in vivo visualization and identification of amyloid deposit in patient. n 16 cl, 2 tbl, 9 dwg, 9 ex |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2766139-C2 |
| priorityDate | 2000-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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