| abstract |
FIELD: medicine; pharmacology. n SUBSTANCE: invention relates to the novel derivatives of 1,2,4-thiadiazole-2-il formula (I), , where R 1 , R 2 and R 4 present the radicals containing cyclic fragments, R 3 designates hydrogen, alkyl, alkenyl or alkinyl that can be used as the agonists and antagonists of melanokortin receptors. Also, in this invention, the pharmaceutical composition, which shows the activity of modulator of melanokortin receptors, and the method of its preparation, are described. The purpose of this invention is to obtain the pharmaceutical compositions, which contain the therapeutically effective amount of compounds, as well as the pharmaceutically acceptable carrier, which are administered to the subject that suffers the melanokortin-mediated diseases, from the group with metabolic disturbances, abnormalities related to CNS and dermatologic abnormalities. n EFFECT: compounds can be used in treatment of CNS and dermatologic diseases. n 21 cl, 13 ex, 13 tbl |