| abstract |
FIELD: organic chemistry, medicine, pharmacy, cosmetology. n SUBSTANCE: invention relates to novel biphenylmethylthiazolidinedions of the general formula (I): , their salts, and to their optical and geometrical isomers possessing agonistic activity with respect to PPARĪ³ receptors, to pharmaceutical and cosmetic compositions based on thereof, and to their using for preparing composition used in treatment of different cutaneous diseases. In compound of the formula (I) R 1 means radical of the following formula (a): or (b): ; R 2 and R 3 mean hydrogen atom; X means binding groups showing the following structures: -CH 2 -N(R 8 )-CO-, -N(R 8 )-CO-N(R 9 )- that can be read from left to right or vice versa; R 4 means phenyl substituted with group R 10 , pyrrolyl, naphthyl, biphenyl, indenyl, benzothienyl and all these groups can be mono- or di-substituted with group R 11 and/or R 12 , group -(CH 2 ) n -(CO) q R 13 , adamantyl, cyclopentylethyl, group -(CH 2 ) n -O-R 13 ; R 5 means hydroxyl or alkoxyl with 1-19 carbon atoms; R 6 means group -OR 14 . Values R 8 , R 9 , R 10 , R 11 , R 12 , R 13 , n and q are given in the invention claim. n EFFECT: valuable medicinal properties of compounds. n 25 cl, 2 dwg, 37 ex |