| abstract |
FIELD: medicine, pharmacy. n SUBSTANCE: invention relates to drugs and concerns a pharmaceutical composition for oral administration and consisting of a mixture that comprises the following components: (i) one or more liquid NO-releasing nonsteroid anti-inflammatory drugs; (ii) one or more nonionogenic surfactants wherein the ratio of NO-releasing a nonsteroid anti-inflammatory agent to a nonionogenic surfactant is from 1:0.3 to 1:3, and (iii) indicated mixture is absorbed on a solid inert carrier to provide preparing a powder in the ration mixture to a solid carrier from 1:2 to 2;1. Proposed composition allows improving the oral bioavailability of liquid drugs. n EFFECT: improved and valuable pharmaceutical properties of compositions and drugs. n 10 cl, 4 tbl, 1 dwg, 8 ex |