http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2320674-C1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f4acedcbac3c479f26b57a1e644d8512 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_30f22dc69868a556f2ca9efef1d75fcf http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bd46c29d4e71dc4dbf26d17c9d779304 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F226-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-465 |
| filingDate | 2006-07-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2008-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c4589924b00eaba2c56f8aa3b54b7aa1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8195ae65aff3d9aed62350177e0cbe53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a307c01fe6955cc6de5ef1c6ab756105 |
| publicationDate | 2008-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2320674-C1 |
| titleOfInvention | Method for preparing n-vinylpyrrolidone copolymer with lauryl methacrylate for transdermal administration of nicotine, copolymer prepared by this method, gel for transdermal administration of nicotine |
| abstract | FIELD: chemistry of polymers. n SUBSTANCE: invention relates to a method for preparing medicinal polymers used in producing nicotine-containing preparations used for smoking lose the habit and possessing stimulating effect, and to nicotine-containing preparations. Invention describes a method for preparing copolymer of N-vinylpyrrolidone with lauryl methacrylate used for the transdermal administration of nicotine. Method involves radical copolymerization of co-monomers of N-vinylpyrrolidone and lauryl methacrylate in the presence of an emulsifying agent, hydrogen peroxide as a initiating agent, ammonium hydroxide and sodium metabisulfite at temperature 70-75°C. As an emulsifying agent nonylphenoxy-(ethoxy) 9 -sulfoacid ammonium salt is used. The process is carried out by preliminary preparing a mixture of ammonium hydroxide, co-monomers, initiating agent, sodium metabisulfite and water and administration of this mixture to the polymerization reactor containing preliminary prepared solution of emulsifying agent. Emulsifying agent solution is prepared by successive administration water to the polymerization reactor, nitrogen bubbling, water heating to temperature 80-85°C, cooling to a polymerization point after saturation of water with nitrogen and administration of emulsifying agent in the mass ratio of water amount used in preparing the mixture containing monomers and amount of water used in preparing solution of emulsifying agent from 20:80 to 40:60, and the polymerization process is carried out at constant bubbling of nitrogen. Increase of prolonged effect of the preparation used for the transdermal administration of nicotine is provides by mixing a prepared copolymer, propylene glycol, cellulose derivative, isopropylmyristate, stearic acid, aerosil, cetyl alcohol, nicotine and ethanol that involves preliminary dissolving water-insoluble copolymer of N-vinylpyrrolidone with unsaturated organic acid ester in ethanol followed by successive addition of propylene glycol and ethanol, and stirring. Then other components are added to the prepared mixture at constant stirring followed by addition of nicotine solution in remained amount of ethanol. n EFFECT: improved preparing method. n 4 cl, 1 tbl |
| priorityDate | 2006-07-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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