abstract |
FIELD: organic chemistry, medicine, pharmacy. n SUBSTANCE: invention describes compound of the formula (I) or its pharmaceutically acceptable salt, or an enantiomer wherein n = 0 or 1; a - b means -CF=CH or -CHFCH 2 ; R 1 represents (C 1 -C 3 )-alkyl wherein alkyl is unsubstituted; R 2 represents hydrogen atom; R 3 is chosen from (C 1 -C 4 )-alkyl, (CH 2 ) n -cycloheteroalkyl and (CH 2 ) n -aryl; or R 2 and R 3 form in common 6-membered saturated ring condensed with 5-membered aromatic ring system comprising 2 heteroatoms chosen from nitrogen atom (N), and pharmaceutical compositions. Compounds of the formula (I) represent modulators of androgen receptors (AR) possessing tissue-selective effect. Proposed compounds are useful as androgen receptors agonists in osseous and/or muscle tissue in antagonizing AR in male patient prostate or in female patient uterus. n EFFECT: valuable medicinal properties of compounds and pharmaceutical composition. n 36 cl, 2 tbl, 72 ex |