http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2319743-C1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_82cc33723ce303553b6a42e3fb95dab4 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-20 |
| filingDate | 2006-08-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2008-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c8a554ea3884de6e1d8ccc13f76a9bdb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9f424d7543bfe642acb5a64c2a10c3f7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8498aebe614c3ae977dd18d78d0f56e6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c292e56c4d1f1c597e43853e934bb913 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6606b069f859d59ab8e9a35b10deb8b3 |
| publicationDate | 2008-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2319743-C1 |
| titleOfInvention | Strain of hybrid cultured mammalian cells mus musculus as producer of monoclonal antibodies to hypoglycosidated and deglycosidated isoforms of tumor-associated human antigen muc i |
| abstract | FIELD: biotechnology, immunology, medicine, oncology. n SUBSTANCE: strain of hybrid cultured mammalian cells Mus musculus VKPM H-98 is prepared by the hybridoma technology method. This strain is a producer of monoclonal antibodies possessing individual specificity to hypoglycosidated and deglycosidated isoforms of tumor-associated human antigen Muc I. Productivity of the strain and specificity of produced antibodies is estimated based on the immunoenzyme assay using some markers of specificity: natural purified antigen Muc I isolated from human milk; VNTR 22 -polypeptide; synthetic monomeric polypeptide (TR 1 ); deglycosidated antigen Muc I (de-Muc I) prepared by chemical oxidation of natural Muc I; hypoglycosidated antigen Muc I (o-Muc I) prepared by periodate oxidation of natural Muc I. Monoclonal antibodies produced by the claimed strain recognize clinically significant isoforms of antigen Muc I and allows assaying its concentrations in human serum blood in carrying out the early diagnosis of tumors. Invention can be used in preparing monoclonal antibodies to tumor-associated human antigen Muc I. n EFFECT: valuable properties of strain. n 2 dwg, 3 ex |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012129325-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10712343-B2 |
| priorityDate | 2006-08-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 27.