http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2319704-C9
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a7f82940e47ba7a1188f8e2ffca55e0f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D493-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D495-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-048 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-444 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-445 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D495-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-048 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4525 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-00 |
| filingDate | 2002-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2008-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1d9bc70549381147ecbf2033f436b9af http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d6f6982e4c34f92d1c10494dcbf27faa http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f743946866911104bc6695575c476882 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8fe0514d9875c9d33f38a7336425b9fc |
| publicationDate | 2008-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2319704-C9 |
| titleOfInvention | Analogs of himbacin, their using and pharmaceutical composition based on thereof possessing property of thrombin receptor antagonist |
| abstract | FIELD: organic chemistry, medicine, pharmacy. n SUBSTANCE: invention relates to heterocycle-substituted tricyclic compounds of the formula (I): or their pharmaceutically acceptable salts wherein R means hydrogen atom; R 1 and R 2 are chosen independently from group comprising hydrogen atom or alkyl comprising 1-6 carbon atoms; R 3 means hydrogen atom; n 1 and n 2 = 0-3 independently under condition that they both do not mean 0; Het means pyridyl wherein pyridyl is added to B through cyclic carbon atom and it comprises from 1 to 4 substitutes (W) chosen independently from group comprising -NR 4 R 5 , -NHCOR 26 , -NHSO 2 R 16 ; R 21 means aryl and R 21 means heteroaryl wherein heteroaryl represents furyl, thienyl, pyridyl, thiazolyl, pyrrolidinyl, azethidinyl; R 4 and R 5 mean hydrogen atom or alkyl comprising 1-6 carbon atoms, or R 4 and R 5 mean in common -(CH 2 ) 3 -, -(CH 2 ) 4 -, -(CH 2 ) 5 - or -(CH 2 ) 2 NR 7 -(CH 2 ) 2 - wherein R 7 means hydrogen atom or alkyl comprising 1-6 carbon atoms; R 8 , R, R 10 and R 11 mean hydrogen atom; B means -(CH 2 ) n4 CR 12 =CR 12a (CH 2 ) n5 wherein n 4 and n 5 = 0-2 independently; R 12 and R 12a are chosen independently from group comprising hydrogen atom or alkyl comprising 1-6 carbon atoms; R 21 means from 1 to 3 substitutes chosen independently from group comprising hydrogen atom, trifluoromethyl, trifluoromethoxy, halogen atom, cyano, alkyl comprising 1-6 carbon atoms, alkoxy group comprising 1-6 carbon atoms, or -CR 29 (=NOR 28 ); R 22 means -COR 23 , -S(O)R 31 , -S(O) 2 R 31 or -COOR 27 ; R 23 means cycloalkyl comprising 3-7 carbon atoms, (C 3 -C 7 )-cycloalkyl-(C 1 -C 6 )-alkyl, cycloalkyl comprising 3-7 carbon atoms containing from 1 to 3 substitutes chosen from group comprising halogen atom, (C 1 -C 3 )-alkoxy-(C 1 -C 3 )-alkyl, hydroxy group and alkoxy group comprising 1-6 carbon atoms, aryl, aryl-(C 2 -C 6 )-alkyl; R 27 means alkyl comprising 1-6 carbon atoms, phenyl or benzyl; R 28 and R 29 are chosen independently from group comprising hydrogen atom or alkyl comprising 1-6 carbon atoms; R 31 means alkyl comprising 1-6 carbon atoms, halogenalkyl comprising 1-6 carbon atoms, aryl, aryl-(C 1 -C 6 )-alkyl. Also, invention relates to pharmaceutical compositions containing these substances and their using for preparing a drug used in treatment of thrombosis, atherosclerosis, restenosis, hypertension, stenocardia, arrhythmia, heart failure and cancer. n EFFECT: valuable medicinal properties of compounds and pharmaceutical composition. n 10 cl, 11 tbl, 9 ex |
| priorityDate | 2001-10-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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