http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2317101-C2
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-08 |
| filingDate | 2002-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2008-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2008-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2317101-C2 |
| titleOfInvention | Novel using dipeptidyl peptidase iv inhibitors |
| abstract | FIELD: organic chemistry, biochemistry, medicine, pharmacy. n SUBSTANCE: invention proposes a pharmaceutical composition used in treatment of patients suffering from cerebrospinal sclerosis. The composition comprises as an active component inhibitor of dipeptidyl peptidase IV (DPIV) of the general formula (I): wherein A means a residue of amino acid comprising at least one functional group in by-side chain; B means oligopeptide comprising up to 20 amino acids in its chain length, or polyethylene glycol of molecular mass up to 20000 g/mole, or optionally substituted organic amine, amide, alcohol, acid or aromatic compound comprising from 8 to 50 carbon atoms representing substituted or optionally substituted phenyl, benzyl, naphthyl, biphenyl and wherein a substitute can mean replacing with one or some groups of alkyl, alkenyl, alkynyl, mono- or multivalent acyl, alkanoyl, alkoxyalkanoyl or alkoxyalkyl as by-side groups; C means group of thiazolidine, pyrrolidine, cyanopyrrolidine, hydroxyproline, dehydroproline or piperidine bound by amide bond with the group A. In animal model study administration of inhibitor DPIV as isoleucylthiazolidine fumarate in the dose 1 mg/kg resulted to the absence of clinical symptoms of disease. In other experiments this inhibitor caused accelerating recovery and shoed anti-inflammatory effect also. n EFFECT: valuable medicinal and biochemical properties of inhibitors. n 4 cl, 8 dwg, 14 ex |
| priorityDate | 2002-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 71.