abstract |
FIELD: medicine, pharmacy. n SUBSTANCE: invention describes immunosuppressive pharmaceutical compositions containing the following components: (a) ISA Tx 247 taken in the pharmaceutically effective amount; (b) vitamin E TPGC (d-α-tocopheryl-polyethylene glycol(1000)-succinate); (c) MCT oil; (d) emulsifier chosen from group consisting of Tween-40 and Tween-80, and (e) ethanol. This pharmaceutical composition forms a clear microemulsion after contact with aqueous medium. Compositions provide high biological availability of drug and/or decrease one or more adverse effects associated with administration of ciclosporin. Also, invention discloses methods for using and preparing these compositions. n EFFECT: valuable medicinal and pharmaceutical properties of compositions. n 39 cl, 7 tbl, 5 dwg, 7 ex |